Chobe can be broken into four areas;

The Serondela area (or Chobe riverfront) features lush floodplains and dense woodland of mahogany, teak and other hardwoods now largely reduced by elephant pressure. Chobe waterfront is the most visited park section, partly because of its proximity to the Victoria Falls. The town of Kasane, situated just downstream, is the most important town of the region and serves as the northern entrance to the park.

The Savuti Marsh area is the western side of the park, and is fed by the Savuti channel and is currently flowing again, this started in 2010 and is the first time water has reached Savuti Marsh since 1982. This region is known for its annual migration of zebra and predators up from the Kalahari desert. Savuti was put on the map when lions were found to be preying on elephants here at one of the main watering holes.

The Linyanti Marsh is known for large concentrations of lion, leopard, wild dog, Roan and Sable antelope, hippopotamuses and large herds of elephants. Red lechwe, sitatunga and crocodile also occur in the area. Birdlife is very rich here. Many camps and lodges have become well known and famous due to these prime game areas.

An area between Linyanti and Savuti Marshes covered by grass and woodland is a great place for spotting eland.